7 Scientifically Proven Health Benefits of Berberine

Berberine has been used for centuries as a natural health remedy. Ancient Assyrians in the Middle East used berberine as a blood purifying agent as far back as 650 BC.* The Assyrians obtained berberine from the fruit of the barberry plant.

Beyond its healing properties, berberine is used as a dye for fabrics as well as a dye used when observing cells under a microscope.*

And berberine continues to be explored and researched to find safe and effective ways to address a wide variety of health concerns.

What is Berberine?

Berberine is a plant-based alkaloid that has been used for thousands of years in Ayurvedic and traditional Chinese medicine. This alkaloid is found in roughly 500 species of plants and is extracted from many parts of the plant including the root, stem, leaves, fruit, and bark.

Plant alkaloids consist of organic nitrogen­-containing substances which can have powerful effects in humans. Because of this, plant alkaloids make up a large portion of plants used in natural medicine.*

What is Berberine Good for?

Historically berberine was used to address inflammation, infection, high blood sugar, and bowel dysfunction. Treating poisonous bites or stings, reducing weight, and wound healing are additional ways in which berberine has been used by practitioners over the centuries, just to name a few.*

Today, berberine is commonly used to support immune function, reduce inflammation, and reduce blood sugar. While the way berberine does all of these wonderful things is still being researched, numerous studies in both animal and human subjects illustrate the powerful effects berberine has on regulating how our bodies process and eliminate sugar as well as other toxins.

#1 Berberine Helps Reduce Inflammation

Berberine has been proven to provide anti-inflammatory properties that benefit brain health, gut health, and nearly everything in between. Berberine has been studied in several neurological conditions and has been linked to protecting the function of the extremely important blood-brain barrier (BBB).*

Anti-inflammatory effects of berberine have also been found in the gut by reducing pro-inflammatory substances known as cytokines.* Studies in animal subjects also found that berberine reduced inflammation and oxidative stress in abdominal fat tissue when the animals were fed a high fat diet. Berberine helped regulate the expression of many pro-inflammatory genes commonly associated with a high fat diet.

#2 Berberine Helps Balance Blood Sugar
(and Get Rid of Fat)

Managing blood sugar may be one of the most popular uses for berberine today. Several studies have proven the powerful effects that berberine has on lowering blood sugar and improving insulin resistance.

Berberine improves how well glucose (sugar) is metabolized and broken down. This is done by activating certain enzymes found in our cells, including adenosine monophosphate-activated protein kinase, or AMPK for short. AMPK is an enzyme connected to metabolism control and has a significant impact on metabolism and how our bodies use sugar – often called the “metabolic master switch”.*

AMPK is responsible for controlling insulin secretion, glucose use, and even how well your liver, pancreas, and muscles break down fat.*

One way berberine does this is to help reduce reactionary insulin spikes which can occur after eating a fatty or high sugar meal. This regulation and steady release of insulin allows for better and more stable glucose tolerance because your body isn’t in a constant state of glucose spikes followed by insulin spikes. **

A study of human subjects with elevated blood sugar found berberine decreased glucose levels in both fasting and non-fasting states.* Berberine was shown to increase glucose disposal rate, putting glucose to work rather than letting it sit around and raise insulin levels and cause other issues).

When glucose-lowering benefits of berberine were studied, researchers also found that berberine reduced oxygen consumption. At first, reducing oxygen sounds like a bad thing, but when it comes to chronically elevated blood sugar, overconsumption of oxygen is a big problem.

Insulin promotes oxygen consumption, taking vital oxygen away from adenosine triphosphate (ATP) which is the chemical compound responsible for converting nutrients into energy. By reducing the available oxygen, cellular damage and dysfunction can occur.*

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#3 Immunity Boost from Berberine

In addition to helping regulate blood sugar levels and insulin activity, berberine gives our immune system a hand when it comes to fighting pathogens. Berberine has been shown to inhibit how viruses attack.* This is in addition to reducing an overactive inflammatory response from your body which is often initiated to fight infection.

This means berberine has an antiviral effect which can help prevent an over-reaction from your own immune system – illustrating just another way berberine helps maintain your good health.

Berberine also has the potential to fight bacterial infections. * This powerful plant alkaloid has shown to be helpful in breaking down common bacteria that can lead to serious infections. Berberine does this by interfering with the bacteria’s DNA, making it difficult for bad bacteria to survive and replicate.

#4 Berberine’s Antioxidative Benefits

Reactive oxygen species, or ROS, are constantly being regulated by your body thanks to antioxidants. If there is an increase in oxidative stress, due to free radicals, sun damage, age, or environmental toxins, then common age-related ailments can emerge.

Berberine has been shown to have potent antioxidant effects – by scavenging for ROS and destroying them. Berberine can also bind to toxins and metals leading to more effective excretion, and also increasing the antioxidative effects of other substances in the body.*

#5 Anti-Aging Benefits of Berberine

In addition to promoting antioxidant activity, berberine has been shown to impact another key element when it comes to aging - thanks again to activating the powerful metabolism switch, AMPK.

Age-related changes are due to many complex causes, but it is well accepted that if your metabolism is working at its highest potential, insulin works better, and fat deposits (especially around the belly) are reduced.

Specifically, the Chinese herb rhizoma coptidis has shown promise as a way to alter age-related cellular processes which can lead to many chronic illnesses often seen in older individuals. Elevated blood pressure and blood sugar, elevated cholesterol, and heart arrhythmias have all been shown to worsen by cellular pathologies related to aging.*

One of the main components of rhizoma coptidis is berberine.

In addition to helping manage age-related changes in vital organs, berberine has been shown to have an anti-aging effect on the skin. Berberine helps stop cellular processes that contribute to skin inflammation and the breakdown of key proteins that give skin its structure and strength.*

Berberine even had an effect on increasing pro-collagen expression in skin cells.* By stimulating pro-collagen production, sun damage, or photoaging, is reduced.

And although more research is needed, berberine has been shown to extend the life span and improve the health of common fruit flies.* Obviously comparing our lives to fruit flies is a large leap, but this species of flies are commonly used for preclinical testing for antiaging therapies thanks to their short life and similar vulnerability to age-related change and decline.

#6 Berberine and Gut Health

When looking at how berberine helps regulate blood glucose and in turn reduces fatty deposits (especially around the belly), it’s important to understand how berberine impacts our gut. When our digestive system isn’t working properly as a result of bacterial imbalance or increased permeability (when nutrients, enzymes and other digestive specific substances leak out of the gut), this can lead to stomach discomfort and inflammation.

Gut dysfunction and the imbalance of healthy bacteria in the gut have been extensively researched and shown to contribute to increased body fat and insulin resistance.* This is thanks to an imbalance between glucose and energy use.

More recently, researchers have found berberine to improve the integrity of the lining of the bowel by reducing intestinal permeability.*

Berberine has also been found to impact the diversity of gut flora, improving its overall balance. Not only can it affect healthy bacteria in the gut, berberine also has the potential to regulate powerful hormones in the gut.

#7 Heart Health Benefits of Berberine

Heart health is another area shown to be directly impacted by berberine supplementation. Ranging from improving how well the heart pumps out blood (ejection fraction) to protecting the heart from pro-inflammatory processes, berberine can help support healthy heart function.*

Berberine also supports the tiny blood vessels and tissues lining the heart, blood vessels, and other organs. Many health problems, including elevated blood sugar, can cause blood vessels to tighten, or constrict, unnecessarily. This can cause chest pain-like symptoms and contribute to the overall dysfunction of these vital blood and nutrient pathways.

Berberine has been shown to help support the dilation, or relaxation, of these blood vessels to restore them to their proper and full function.*

Berberine also helps regulate lipid (fat) deposits inside the blood vessels. As we age, these sticky lipids can attach themselves to the walls of veins and arteries, causing them to become stiff and narrow.

Studies with berberine supplements have been shown to not only protect against this lipid buildup but also help reduce buildup if it has already occurred.**

Finding a Superior Berberine Supplement

It’s clear that berberine is chock full of health benefits. But it’s not as simple as finding a plant rich in berberine and snacking on the bark.

Extracting berberine has been proven to be more complicated than many other compounds due to its high sensitivity to light and heat. Both of these stimuli can damage and degrade the usefulness of berberine.*

Here are six reasons why NAOMI Berberine is a superior berberine supplement:

• Features the Pure Extract, Berberine HCI.
  This phytochemical is isolated and extracted from the berberis plant to give you the highest concentration of healing power possible.
• Includes Research-Level Dosage.
  At 1,000 mg you are getting the clinically proven amount of berberine every day.
• Free of Magnesium Stearate.
  There are many concerns about the safety of this commonly used additive. In my opinion, the risk isn’t worth it – so I guarantee you won’t find it here.
• No unnecessary binders, fillers or dyes.
  These ingredients sometimes used in other products may trigger allergic reactions – or even depress immune function.
• Quality You Can Trust.
  NAOMI Berberine is manufactured in a state-of-the-art, FDA-inspected facility in the United States and is independently tested for purity and potency. You should never settle for supplements manufactured in dubious conditions overseas.
• Affordably Priced, Ships for Free and Risk Free.
  NAOMI Berberine is amazingly affordable, as low as $20 per bottle for a full month’s supply. It also ships to you for free and is backed by an industry-leading 365-day, 100% satisfaction, full refund guarantee so you can try it without risk.