Cholesterol – What’s The Real Truth?


You might recall the anti-cholesterol craze of the 1980’s when decreasing saturated fat and dietary cholesterol were considered the most critical dietary changes you could make to save your heart.  Turns out, if you worried about your fat intake like so many did, it was a complete waste of time. Here’s why.

The healthcare community was recommending eating everything low-fat and steering clear of dietary sources of cholesterol for fear of raising blood cholesterol levels, particularly the “bad” cholesterol (low-density lipoprotein or LDL).  Even foods like peanut butter, which never contained cholesterol in the first place, were labeled as cholesterol-free. It’s as though the more we could label as “free” the more we felt free to eat. So for decades foods such as cod liver oil and egg yolks were demonized without clear evidence they contributed to risk of disease. They certainly weren’t “free” so of course, we were terrified of them.  But at what cost?

What we know now is that there is no direct correlation between the amount of cholesterol you eat and the amount in your blood. The liver makes about ¾ of your body’s cholesterol, and only about 30% of the population might see dietary cholesterol increasing concentration of blood cholesterol. But contrary to what some might still be led to believe, dietary cholesterol increases the “good” cholesterol (high-density lipoprotein or HDL) and may, in fact, promote health – not destruct it!

The First Truth: Cholesterol is Essential

The mere mention of the word cholesterol might conjure up negativity, but the fact is that this soft, waxy substance found in the bloodstream and in every cell in the body is essential.

It plays a positive role in many physiological processes:

  • It is a component of cell membranes needed to maintain proper membrane permeability and fluidity.
  • It is a precursor for the synthesis of steroid hormones estrogen, testosterone, and progesterone which affect sex characteristics, development, and pregnancy.
  • It is a precursor for the glucocorticoid hormones (such as cortisol) which are involved with many aspects of metabolism, stress-response, and inhibition of the inflammatory response.
  • It is needed for synthesis of mineralocorticoid hormones (such as aldosterone) which are involved in mineral electrolyte balance and blood pressure regulation.
  • Although fortified foods and some animal foods contain small amounts of vitamin D, your body’s ability to produce this important hormone (yes, Vitamin D is technically a hormone!) depends on cholesterol as a starting material.
  • It is necessary for the production of bile acids which help with fat digestion and absorption of fat-soluble nutrients.
    It supports the development of synapses in the brain, essential for learning and memory.

The Good, The Bad, The Ugly

Since I talk to you a lot about fats, let’s quickly talk about good fats and cholesterol versus bad fats and cholesterol. 

HDL is often referred to as the “good” type of cholesterol as it helps keep cholesterol away from arteries and from building up as arterial plaque, which is a factor in the development of heart disease.

LDL has been deemed “bad” cholesterol because historically it has been suggested to contribute to plaque buildup, making the arteries less flexible and narrower which is the basis for atherosclerosis. The idea that fats are bad stems from the notion that foods containing fat and cholesterol will lead to heart disease.  What we now know is that it’s not fat or cholesterol themselves that are an issue, but the problem lies in the breakdown of UNSTABLE fats, particularly the oxidation of polyunsaturated fatty acids (PUFA’s) found in vegetable oils (like corn, canola, cottonseed, soy, safflower, sunflower) that we have been told for decades are healthier for us than animal fats but are actually prone to oxidation.

In 2013, Dr. Fred Kummerow published a paper reviewing over 60 years of research on dietary factors – especially oxidized cholesterol – that contribute to heart disease. The premise is that when fats degrade, a free radical chain reaction ensues, leading to cell damage. In the late Dr. Kummerow’s view and the opinion of an increasing number of experts, the primary cause of heart disease is oxidized cholesterol and fats. The point is that scientists have known for a while now that the cholesterol that dangerously builds up in artery walls is oxidized LDL and that is what contributes to atherosclerosis.  

While decades of studies suggest that PUFA’s will increase how fast LDL is removed from the blood, what we weren’t taught is that PUFA’s do so by attaching to LDL particles which makes that LDL more unstable and vulnerable to oxidation. So although PUFA’s may cause cholesterol to go down, there may be a hidden price in terms of risk for heart disease due to oxidation.  

In addition to consuming excess PUFA’s, other contributors to the build-up of oxidized cholesterol in the bloodstream include consuming partially hydrogenated oils or trans fats, eating processed foods such as commercially fried chicken, French fries, margarine, and commercial baked goods, as well as cigarette smoking.

The Final Truth: Preventing Oxidative Damage

Your first priority to take back your heart health (and overall health too!) is to reduce your intake of oxidized PUFA’s.  This is a good first step to reducing damage from oxidized LDL. It’s why I encourage the use of good fats and recommend against those that are unstable. I also recommend increasing intake of “Powerphenols”, a term I coined to describe some of the most powerful polyphenols of the plant kingdom that not only provide potent antioxidant activity but also activate your body’s natural recycling process to remove toxins and repair damage left behind, a process called autophagy which is the basis of my Glow15 lifestyle plan. Some studies have suggested that one of my favorite powerphenols, curcumin, may be helpful for minimizing the amount of time LDL spends in the bloodstream.  Additionally, limiting or ideally avoiding all added sugars and processed, refined carbohydrates from your diet will drastically reduce your risk of heart disease due to improvements in triglycerides, insulin sensitivity, and C-reactive protein levels.

Although preventing oxidized damage through diet, supplements, and lifestyle rather than responding to lab tests is more my cup of tea, it is important to remember that lab tests can help identify if there are deeper issues going on which might also affect LDL receptor function.

You’ll want to ensure your liver, thyroid, insulin and general level of inflammation are all normal and healthy. If you are concerned about risk for heart disease, have been “diagnosed” with high cholesterol, or simply want to discern what is going on in your body a little better, have your practitioner look at these labs, which may be indicative of metabolic issues deep within:


  • Total cholesterol to HDL ratio (this assesses the amount of HDL available to recycle LDL from blood before it has a chance to become oxidized)
  • LDL particle size via an NMR or VAP test (or an APOB test) which evaluates particle size and assess oxidation-prone state (this is by far more diagnostic than just an LDL value alone)
  • Thyroid function
  • Insulin function
  • Inflammation level via CRP
Additionally, don’t undervalue the role that stress and sleep play in maintaining the healthy metabolic pathways your body utilizes to promote normal cholesterol levels in the body.  Although stress can sometimes be unavoidable, there are certain lifestyle adjustments to minimize the effect of bad stress:
  • Consume a healthy diet
  • Participate in regular physical activity
  • Practice meditation, yoga or whatever spiritual activity speaks to your soul
Lastly, I believe that all of these preventative measures can be achieved by adhering to the lifestyle and dietary suggestions that have been incorporated into my New York Times Best Selling Book, Glow15. Enjoy!

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