Intermittent Fasting: A Guide to Weight Loss and Total-Body Benefits

Intermittent fasting is the practice of shifting between short intervals of restricted eating. In practice, this works by giving your body periods of calorie restriction—a time in which your body is not getting any calories (which gives your cells a chance to re-charge and repair). One common way to do it is by simply skipping breakfast, which basically means that you would fast for 16 hours (though the practice has many variations). There are many reported benefits of intermittent fasting, including that it can help you lose weight and make your risk lower for a variety of medical conditions.[*]

I practice intermittent fasting, as well as protein cycling, as part of the keto lifestyle. And I love the way intermittent fasting makes me feel. I can feel increased—and steady—energy all throughout the day. It helps me maintain my weight. That also has a lot to do with the other foods I eat, and making sure to eat fat as part of the first thing I eat every day. Now, you probably have heard a lot about fasting, and it may even scare you a bit. Not eat? For 16 hours at a time? I know how you feel. It feels like it could be a stomach-growling, mad-at-the-world challenge to undertake. But it’s really not, when you consider that a large portion of that time can be when you’re sleeping.

So often, I find that people frame “fasting” around deprivation. For me? I think of it as opportunity. An opportunity to improve my health. An opportunity to spend a few days per week giving my cells a chance to go through a refresh. An opportunity to see so many health benefits. An opportunity to give my body an all-natural—and fairly simple—boost of youth are part of intermittent fasting benefits.

What is Intermittent Fasting?

Lamps, computers, and crazy relatives aren’t the only things that need an on-and-off switch. Your body needs one, too. That’s because the inside of your body via your cells needs time to clean up and repair itself (that’s autophagy). Most of us, however, spend our days in a constant state of eating (not literally every minute of the day, of course)—from the time we wake up until the time we go to bed and quite a few times in between. When you’re eating, a couple things happen: Your digestion systems are always revving, for one; and you’re also pumping your body full of glucose for your body to use for energy as fuel. Your body works hard to process it all. But your body—like you in the middle of a hard day—sometimes needs a break. This break involves eating and not eating for a period of time. That cycling between calorie intake and no calories at all is intermittent fasting.

How Intermittent Fasting Works

When you go through extended periods without food, your body reacts to that in a number of ways.[*]

Some of them:

  • Your body becomes stressed in a positive way, not in a “what the heck are you doing?” way. That’s what triggers the cellular detoxification process of autophagy. Autophagy is what helps reduce your chances of developing chronic diseases and metabolic disorders and live a longer, active life.
  • Your insulin levels go down, and your glucagon levels go up. Glucagon is a hormone released by the pancreas to address low blood glucose. This is a good thing because it’s like the “on” switch for autophagy. That has been shown to have such benefits as increasing metabolism, providing more energy, improving mood, and jumpstarting weight loss.[*][*]
  • You increase the diversity of bacteria in your gut, which is important for immune health. Researchers have linked daily fasting to activation of the gene that strengthens the gut barrier to protect the body from harmful microbes, toxins, and other substances that can trigger immune reactions.

What is Protein Cycling?

To me, “protein cycling” and intermittent fasting go together like dark chocolate and red wine. Perfect partners. Protein cycling is the practice of alternating between periods of low protein consumption and normal to high protein consumption. The reason you want to under-eat protein on some days of the week is similar to why you want to start intermittent fasting: it all comes back to the dance between glucagon and insulin. Lowered protein intake means lowered insulin levels and higher glucagon, which means you’ll activate autophagy. Since your body can’t make its own protein, if you don’t eat it (or eat enough of it), then it’s forced into recycling its existing proteins. This recycling activity is a fundamental task of the autophagy process.

Health Benefits of Intermittent Fasting

Gut Health

Fasting can increase the diversity of bacteria in your gut, which is important for your immune and overall health.[*] A healthy gut microflora is pertinent to digestive health which directly influences your immune health, your hormones, neurotransmitters, nutrient status, mitochondrial function, adrenal status and most importantly, whether or not your inflammatory response works for or against your health.[*][*]

Brain Health

Researchers observe that fasting pushes you to produce more chemicals (like brain-derived neurotrophic factor or BDNF) that tell neurons to grow and speak with other neurons.[*][*][*] BDNF can lower oxidative stress and inflammation, reduce your resting heart rate, and likely boost your brain power. In addition, scientists now better understand that brain cells respond to short-term food restriction with an increase in autophagy (remember, it’s your cellular clean-up system).[*]

Other studies have shown that fasting can reduce brain inflammation, protect neurons from memory deficits caused by damage to the hippocampus, thicken the hippocampus with better learning performance, reduce plaques associated with Alzheimer’s, and more.[*][*][*][*]

Better Blood Sugar

By supporting balanced blood sugar and improving insulin sensitivity, fasting reduces brain cell damage from glucose (glycation). When you fast intermittently, insulin levels go down (thus decreasing insulin resistance) and glucagon goes up which has been shown to have benefits like increased metabolism, more energy, improved mood, and weight loss.[*]

Heart Health

Mouse models have shown alternate day fasting can reduce cardiovascular disease risk by improving cholesterol and triglyceride levels.[*] And another study of obese women showed that when practicing intermittent fasting, LDL and total cholesterol levels decreased (as well as body weight and fat mass).[*][*] More research showed that fasting helped improve healthy cholesterol (HDL) and decreased unhealthy cholesterol (LDL) over four weeks.[*]

Weight Loss and Control

Intermittent fasting for weight loss – One study with over 300 obese adult participants concluded that eating or skipping breakfast had no connection to obesity.[*][*] Other studies have suggested that skipping breakfast can actually be an effective weight loss tool for certain people. Another study of obese women undergoing intermittent fasting for 6 months saw subject burn fat with a reduction on average of 14 pounds,[*] while another study sound that that overweight subjects lost 8% of their body fat in 8 weeks of intermittent fasting.[*] Other research has shown that it can improve muscle mass as well.[*]


Several animal studies have found promising results on the potential lifespan-extending effects of fasting.[*][*] For example, when rats were put caloric restriction/intermittent fasting schedule, the study showed that the mean life span of the fasting group represented an 83% increase over that of the other group.[*] And another study showed that mice fed 60% of normal caloric intake or that underwent intermittent fasting lived from two to three times longer than their paired full-fed mice.[*]

History of Intermittent Fasting

In the 1700s, founding father Benjamin Franklin—also known for his health acumen—said, “The best of all medicines are resting and fasting.” He knew it before science gave us insights into the benefits of fasting, but he wasn’t the first: Billions of years ago, organisms had to respond and adapt to starvation conditions—meaning that our bodies have evolved to figure out how to best utilize these periods without fuel.

Some have made the argument that cultures from the Middle Ages considered breakfast a form of gluttony. And fasting, as you likely know, has also been a foundational part of many religious practices, such as Jewish people fasting for 24 hours on Yom Kippur and Muslims practicing fasting during the holy month of Ramadan. Fascinating studies have been done on Muslim people, showing that periods of fasting are related to reduced markers of inflammation and heart disease.[*] (Researchers have also found increases in energy for fasting periods, which may not be what you would expect.)[*][*] In addition, fasting has been used as a medicinal tool to treat chronic conditions such as type 2 diabetes and other metabolic disorders such as obesity for hundreds of years.

How to Practice Intermittent Fasting

Like coffee orders and phone cases, choices for how to do intermittent fasting are seemingly limitless. One kind if the 5:2 or 6:1 approach, which means you eat normally for five or six days and then have fasting days. For the other one or two days of the week, you reduce calorie intake to about 500 calories a day. Another kind is the Eat Stop Eat method, which is doing a 24-hour fast for one or two days a week. I, however, prefer the 16:8 method, because I think it is not only effective but is also the most reasonable to manage (a recent study shows that it’s likely easier to follow than other protocols).[*]

This means you eat during an 8-hour window during the day and fast for 16 (including your sleep hours). This is the one I practice and talk about in-depth in my book, Glow15. When doing it, the only thing you need to really think about is skipping breakfast and not eating late at night; that’s what gives you your 16-hour fasting window.

Research also shows that 16 hours is the optimal amount of time for creating the caloric restriction that happens during fasting and to activate autophagy.

Risk Factors of Intermittent Fasting

If you have a medical condition, you should consult with your doctor before trying intermittent fasting to make sure side effects of adjusting to a new way of eating don’t have influence on other health issues.

This applies especially if you:

  • Have diabetes.
  • Have problems with blood sugar regulation.
  • Have low blood pressure.
  • Take medications.
  • Are underweight.
  • Have a history of eating disorders.
  • Are a woman who is trying to conceive.
  • Are pregnant or breastfeeding.

Intermittent Fasting for Beginners

New to fasting?

It’s natural to feel intimidated the first time you try something new Here’s a simple way to get started:

  • Step 1: At 8:00 p.m., stop eating.
  • Step 2: Fast for 12 hours until 8:00 a.m.
  • Step 3: If this is comfortable for you, challenge yourself to a 14-hour fast next time. Remain at that duration until it feels comfortable. Your ultimate goal is to fast for 16 hours, then break your fast at noon.
  • Break your fast gently with an egg, a cup of broth, or coffee with Simply GOODFATS MCT oil. The extra fat in these foods provide your body with energy without spiking insulin, as foods high in carbohydrates would do.

Intermittent Fasting Summary:

  • Intermittent fasting is the practice of cycling periods of eating and calorie restriction.
  • Intermittent fasting has been shown to have many benefits, including improve heart health and brain health, as well as weight loss and weight control.
  • While it has many varieties, you can practice a 16:8 cycle (8-hour window of eating with 16 hours of fasting—inclduing the hours ypu’re sleeping).